What is Kratom’s Active Component and History

What is Kratom’s Active Component

Mitragyna speciosa (Rubiaceae) has traditionally been used as a substitute for opium. The phytochemical studies conducted on the constituents of this plant being grown in Indonesia, Malaysia and Thailand reveal that almost 25 alkaloids can be isolated from Mitragyna Speciosa. The highest number of alkaloids consists of two oxindoles and three indoles, which are paynanthine, mitragynine and speciogynine. The two oxindoles are speciofoline and mitraphylline. There are some other alkaloids as well including corynanthedine, ajmalicine, rhychophylline, mitraversine and stipulatine.